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  1. Myocardial contractility

    Myocardial contractility represents the innate ability of the heart muscle to contract. It is the maximum attainable value for the force of contraction of a given heart. The ability to produce changes in force during contraction result from incremental degrees of binding between different types of tissue, that is, between filaments of myosin and actin tissue. The degree of binding depends upon the concentration of calcium ions in the cell. Within an in vivo intact heart, the action/response of the sympathetic nervous system is driven by precisely timed releases of a catecholamine, which is a process that determines the concentration of calcium ions in the cytosol of cardiac muscle cells. The factors causing an increase in contractility work by causing an increase in intracellular calcium ions during contraction. Wikipedia

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  2. sciencedirect.com

    Contractility is the intrinsic ability of cardiac muscle to contract at a given sarcomere length. Learn about the factors that affect contractility in fishes and other vertebrates, and the force-frequency relationship of cardiac muscle.
  3. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › books › NBK54082

    The use of the term contractility goes back well over a 125 years, and was used to simply describe a property of assorted tissues to shorten. The term has something to do with the ability of heart tissue to shorten, but has taken on new connotations in current thinking. Moreover, with the state of detailed knowledge of molecular and cellular control of the level of activity and dynamics of the ...
    Author:R. John SolaroPublished:2011
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  5. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › books › NBK54078

    Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from ...
    Author:R. John SolaroPublished:2010
  6. pmc.ncbi.nlm.nih.gov

    Muscle contractility and cell motility play a vital role in various physiological and pathological processes, ranging from animal locomotion to cardiovascular function to myopathies and heart failure. Actin-activated myosin II motors power muscle contraction and non-muscle-cell motility. Actin-myosin-derived contractility has been most ...
  7. pmc.ncbi.nlm.nih.gov

    Abstract. The term myocardial contractility is thought to have originated more than 125 years ago and has remained and enigma ever since. Although the term is frequently used in textbooks, editorials and contemporary manuscripts its definition remains illusive often being conflated with cardiac performance or inotropy.
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