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  1. Jan 14, 2025In a preprint study, scientists from Lifespan Research Institute and the Buck Institute for Research on Aging have published their findings that Urolithin A, a molecule that has garnered a lot of attention in the longevity field, potently reduces senescence-related markers in human fibroblasts [1]. Senolytic versus senomorphic
  2. pmc.ncbi.nlm.nih.gov

    In this regard, diverse metabolites of the gut microbiome and probiotic bacteria, or microbiome-fermented dietary phytomolecules are known to exert strong anti-inflammatory and antioxidant attributes which may be useful in preventing senescence-associated pro-inflammatory and pro-tumorigenic environment [137-142] (Fig. 3).
  3. sciencedirect.com

    4 days agoIn this review, we explore the interconnection between dietary phytochemicals and gut microbiota in promoting both gut health and healthy aging and explore how microbial metabolites may prevent or delay the development of age-related diseases including cancer, neurodegeneration, cardiovascular and metabolic diseases, and disorders of the musculoskeletal and immune systems (Figure 1).
  4. pmc.ncbi.nlm.nih.gov

    A summary of the multifaceted features of senescent cells and their impact on the gut microbiome. Cellular senescence arises from myriad stimuli, including DNA damage, telomere shortening, and oxidative stress, which disrupt normal cellular functions and induce cell cycle arrest through key pathways such as p16 INK4A ‐pRB and p53-p21 WAF1/CIP1. ...
  5. sciencedirect.com

    Aug 1, 2024Furthermore, senescent cells secrete inflammatory substances as a senescence-associated secretory phenotype (SASP) [22., 23., 24.], and it has been shown to induce chronic inflammation and promote age-related deterioration of biological functions and the development of various diseases, including cancer, depending on the biological context [25 ...
  6. sciencedirect.com

    Dec 1, 2024Polysaccharides, the main active ingredients of TCM, have been widely studied for their rich pharmacological activities, such as anti-inflammatory, antioxidant, and anti-tumor effects (Li et al., 2020a; Shao et al., 2014; Tian et al., 2023).Among them, the regulation of gut microbiota is the main way by which the polysaccharides in TCM exert pharmacological activity, mainly because the gut ...
  7. pubmed.ncbi.nlm.nih.gov

    Cellular senescence, characterized by a cessation of cell division in response to various stressors, induces morphological and functional changes within tissues. The complexity and heterogeneity of senescent cells, alongside the secretion of senescence-associated secretory phenotype, exacerbate the aging process through pro-inflammatory ...
  8. advances.nutrition.org

    5 days agoThis comprehensive and novel review highlights the critical connection between dietary phytochemicals, gut microbiota and healthy aging. In particular, the review focuses crucial insights on how specific phytochemicals and gut microbiota interact to generate unique plant-derived microbial metabolites that have profound potential to positively influence healthspan by preventing or delaying the ...

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