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  1. chemistry-europe.onlinelibrary.wiley.com

    Aug 21, 2023Their use is often possible only when the enzyme-catalytic mechanism is thoroughly known. Thus, atomic-level knowledge of a Michaelis enzyme-substrate complex, revealing molecular details of substrate recognition and catalytic chemistry, is crucial for understanding and then rationally extending or improving enzyme-catalyzed reactions.
  2. loschmidt.chemi.muni.cz

    Dec 13, 2024Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues Authors. Gao, T., Damborsky, J., Janin, Y. L., Marek, M. ... atomic-level knowledge of a Michaelis enzyme-substrate complex, revealing molecular details of substrate recognition and catalytic chemistry, is crucial for understanding and then rationally extending or ...
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  4. semanticscholar.org

    It is suggested that an analogous strategy can be applied to various enzymes with unknown catalytic mechanisms and poor crystallizability, focusing on the recent discovery of a Renilla‐type bioluminescence reaction mechanism facilitated by a combination of engineered ancestral enzyme and the availability of a non‐oxidizable luciferin analogue. Environmentally friendly industrial and ...
  5. researchgate.net

    Sep 8, 2023Download Citation | Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues | Environmentally friendly industrial and biotech processes greatly benefit from enzyme‐based ...
  6. bioweb.supagro.inrae.fr

    Title : Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues - Gao_2023_ChemCatChem_15_e202300745: ... Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues ChemCatChem 15:e202300745. Gao T, Damborsky J, Janin YL, Marek M (2023)
  7. citedrive.com

    Environmentally friendly industrial and biotech processes greatly benefit from enzyme‐based technologies. Their use is often possible only when the enzyme‐catalytic mechanism is thoroughly known. Thus, atomic‐level knowledge of a Michaelis enzyme‐substrate complex, revealing molecular details of substrate recognition and catalytic chemistry, is crucial for understanding and then ...
  8. Many known enzymes sample huge protein conformational space, hampering structural characterization by X-ray crystallography, and preventing thus the understanding of their catalytic mechanisms. In this review, we outline that the combination of reconstructed ancestral enzymes with unconvertible substrate analogues is becoming a powerful strategy to decipher the challenging mechanisms of enzyme ...
  9. pubs.acs.org

    A widely accepted hypothesis of enzyme evolution is that extant enzymes originate from biocatalysts that were adapted to different fitness landscapes,5 as was shown, e.g., for pancreatic artiodactyl ribonucleases that emerged from non-digestive ancestral ribonucleases.6 Amino acid or DNA sequences of putative ancestral enzymes can be computation-
  10. lib.braou.ac.in

    Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues Posted on 9 October 2023 by nTadeja Gao., nJiri Damborsky., nYves L. Janin, nMartin Marek.n ChemCatChem, Volume 15, Issue 19, October 6, 2023.

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