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  1. pubmed.ncbi.nlm.nih.gov

    Here, we use experiment and theory to examine active microtubule networks driven by mixtures of motors with opposite directionality and different cross-linker design. We find that although the kinesin-14 HSET causes network contraction when dominant, it can also assist the opposing kinesin-5 KIF11 to generate extensile networks.
  2. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC9388136

    The spindle is a highly interconnected network of microtubule filaments that are cross-linked by different types of molecular motors. How the different motors cooperate to organize the spindle network is not understood. Here, we show that an asymmetric cross-linker design can confer bifunctionality to a mitotic motor in the presence of other ...
  3. cross-linking motors arrange the microtubules in such a network is not understood. In vitro reconstitutions of self-organizing microtubule networks with purified cross-linking motors have provided insight into the basic properties of active microtubule-based networks (5, 6, 8-16). Mixtures of microtubules with a single type of cross-linking
  4. semanticscholar.org

    It is shown that an asymmetric crosslinker design can confer bifunctionality to a mitotic motor in the presence of other motors, which defines new rules controlling the generation of active microtubule networks and allows a better understanding of motor cooperation in the spindle. During cell division, crosslinking motors determine the architecture of the spindle, a dynamic microtubule network ...
  5. Feb 17, 2023Here we studied two important control parameters of active microtubule network organization that have so far escaped substantial theoretical investigation: (i) short-range depletion forces between microtubules and (ii) the length of microtubules. ... Cross-linker design determines microtubule network organization by opposing motors. Proc. Natl ...
  6. researchgate.net

    PDF | During cell division, crosslinking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the... | Find, read and cite all the research you need on ...
  7. During cell division, crosslinking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes. It is unclear how motors with opposite directionality coordinate to drive both contractile and extensile behaviors in the spindle. Particularly, the impact of different crosslinker designs on network self-organization is not understood, limiting ...
  8. repositori.upf.edu

    Cross-linker design determines microtubule network organization by opposing motors. ... Henkin G, Chew WX, Nédélec F, Surrey T. Cross-linker design determines microtubule network organization by opposing motors. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2206398119. DOI: 10.1073/pnas.2206398119: dc.identifier.issn: 0027-8424:
  9. During cell division, cross-linking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear how motors with opposite directionality coordinate to drive both contractile and extensile behaviors in the spindle.

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