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  1. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC9388136

    These experiments demonstrate that the asymmetric design of HSET, with its motor domains positioned opposite the diffusible microtubule binding tail domains, turns this motor into a multifunctional cross-linker that can either assist KIF11 in nematic network formation or promote contractile network and aster formation depending on the relative ...
  2. microtubule bundler. Our study illustrates how the design of mitotic motors is optimized for their combined action in the spindle and provides insight into the principles of active multi-motor network organization. Results The Organizational Capacities of HSET and KIF11 Diverge at High Tubulin Concentrations.Recently, we systematically
  3. pubmed.ncbi.nlm.nih.gov

    Here, we use experiment and theory to examine active microtubule networks driven by mixtures of motors with opposite directionality and different cross-linker design. We find that although the kinesin-14 HSET causes network contraction when dominant, it can also assist the opposing kinesin-5 KIF11 to generate extensile networks.
  4. Cross-linker design determines microtubule network organization by opposing motors. Gil Henkin https: ... This bifunctionality results from HSET's asymmetric design, distinct from symmetric KIF11. ... Cross-linker design determines microtubule network organization by opposing motors. Proceedings of the National Academy of Sciences. Vol. 119;
  5. During cell division, crosslinking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes. It is unclear how motors with opposite directionality coordinate to drive both contractile and extensile behaviors in the spindle. Particularly, the impact of different crosslinker designs on network self-organization is not understood, limiting ...
  6. semanticscholar.org

    It is shown that an asymmetric crosslinker design can confer bifunctionality to a mitotic motor in the presence of other motors, which defines new rules controlling the generation of active microtubule networks and allows a better understanding of motor cooperation in the spindle. During cell division, crosslinking motors determine the architecture of the spindle, a dynamic microtubule network ...
  7. researchgate.net

    PDF | During cell division, crosslinking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the... | Find, read and cite all the research you need on ...
  8. ui.adsabs.harvard.edu

    The spindle is a highly interconnected network of microtubule filaments that are cross-linked by different types of molecular motors. How the different motors cooperate to organize the spindle network is not understood. Here, we show that an asymmetric cross-linker design can confer bifunctionality to a mitotic motor in the presence of other ...
  9. repository.cam.ac.uk

    During cell division, cross-linking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear how motors with opposite directionality coordinate to drive both contractile and extensile behaviors in the spindle. Particularly, the impact of different cross-linker designs on network self-organization is not ...
  10. pmc.ncbi.nlm.nih.gov

    Together, these triple inhibition experiments reveal that redundant motors and crosslinkers can generate bipolar spindles in the absence of NuMA and Eg5. However, these spindles are sensitized to changes in motor activity, microtubule organization and dynamics—biochemical fluctuations to which the wild-type spindle is robust.

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