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  1. embopress.org

    The physicochemical drivers of the biogenesis, maintenance, and disassembly of compartments, and their ability to concentrate macromolecules without an encapsulating membrane, have attracted considerable interest (Banani et al, 2017; Shin & Brangwynne, 2017).Molecular mechanistic biology, with its focus on the identification, characterization, and visualization of discrete and highly specific ...
  2. embopress.org

    I also discuss that highly specific interactions, rather than unspecific ones, appear to be the main driver of biogenesis of subcellular compartments, while phase separation may be harnessed locally in selected instances to generate material properties tailored for specific functions, as exemplified by nucleocytoplasmic transport.
  3. pubmed.ncbi.nlm.nih.gov

    On the role of phase separation in the biogenesis of membraneless compartments EMBO J. 2022 Mar 1;41(5):e109952. doi: 10.15252/embj.2021109952. Epub 2022 Feb 2. Author ... weakly adhesive unspecific interactions as the driver of biogenesis of membraneless compartments. Here, I discuss the molecular underpinnings of the phase separation paradigm ...
  4. mpi-dortmund.mpg.de

    On the role of phase separation in the biogenesis of membraneless compartments. Musacchio A (2022) EMBO J. Source. ... The biogenesis of membraneless cellular compartments, functional mesoscale subcellular locales devoid of strong internal order and delimiting membranes, is among mechanistic biology's most demanding current challenges. ...
  5. researchgate.net

    The biogenesis of membraneless cellular compartments, functional mesoscale subcellular locales devoid of strong internal order and delimiting membranes, is among mechanistic biology's most ...
  6. europepmc.org

    The potential of the concept of "phase separation" (PS) to explain several biological and pathological phenomena is currently an extremely hot and controversial topic. In this review, Musacchio casts a critical eye over much of the fields current thinking on how PS might apply to the formation of membraneless compartments.
  7. pmc.ncbi.nlm.nih.gov

    Liquid-liquid phase separation (LLPS, also known as biomolecular condensation) and the related biogenesis of various membraneless organelles (MLOs) and biomolecular condensates (BMCs) are now considered fundamental molecular mechanisms governing the spatiotemporal organization of the intracellular space [1,2,3,4,5].Physically, LLPS represents a special case of phase transition taking place ...
  8. Recent investigations in bacteria suggest that membraneless organelles play a crucial role in the subcellular organization of bacterial cells. However, the biochemical functions and assembly mechanisms of these compartments have not yet been completely characterized. This article assesses the current methodologies used in the study of membraneless organelles in bacteria, highlights the ...
  9. Liquid-liquid phase separation (LLPS) drives the formation of membraneless compartments in eukaryotic cells, such as P granules, nucleoli, heterochromatin, and stress granules (1-5), enabling concentrations of associated biomolecules to increase biochemical reaction efficiency and protection of mRNA or proteins to promote cell survival under stress.
  10. embopress.org

    The biogenesis of membraneless cellular compartments, functional mesoscale subcel-lular locales devoid of strong internal order and delimiting membranes, is among mecha-nisticbiology'smostdemandingcurrentchal-lenges. A developing paradigm, biomolecular phase separation, emphasizes solvation of the building blocks through low-affinity,

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