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  1. embopress.org

    May 19, 2023In human cells, a bioriented kinetochore contains approximately 250 copies of the Ndc80 complex (Suzuki et al, 2015) and binds a bundle of approximately 10 microtubules, known as a k‐fiber (O'Toole et al, 2020; Kiewisz et al, 2022).Thus, a single microtubule in the k‐fiber binds multiple Ndc80 complexes (Fig 1A).Reinforcing this prediction, single Ndc80 complexes fail to bind to the ends ...
  2. embopress.org

    May 19, 2023Multiple copies of the extended Ndc80 complex mediate microtubule binding at each kinetochore. This study finds that homotypic interactions between Ndc80 complexes mediated by a loop region enable stable attachment of kinetochores to dynamic microtubule ends, explaining the crucial role of the Ndc80 loop during mitosis.
  3. pubmed.ncbi.nlm.nih.gov

    Jul 3, 2023This arrest is not due to an inability to recruit the kinetochore-microtubule stabilizing SKA complex and cannot be overridden by mutations in the Ndc80 tail that strengthen microtubule attachment. Thus, loop-mediated organization of adjacent Ndc80 complexes is crucial for stable end-on kinetochore-microtubule attachment and spindle assembly ...
  4. During cell division, kinetochores link chromosomes to spindle microtubules. The Ndc80 complex, a crucial microtubule binder, populates each kinetochore with dozens of copies. Whether adjacent Ndc80 complexes cooperate to promote microtubule binding remains unclear. Here we demonstrate that the Ndc80 loop, a short sequence identified across eukaryotes and predicted to interrupt the Ndc80 ...
  5. pubmed.ncbi.nlm.nih.gov

    Precisely how the inhibitory SAC signal is extinguished in response to microtubule attachment remains unresolved. To address this, we induced formation of hyper-stable kinetochore-microtubule attachments in human cells using a non-phosphorylatable version of the protein Hec1, a core component of the attachment machinery.
  6. europepmc.org

    Open in new tab Figure 1: Structural analysis and loop-dependent clustering of Ndc80 on microtubules.. A) Cartoon of a chromosome pair during mitosis with sister kinetochores that are attached (green) and unattached (red) to microtubules.The unattached kinetochores trigger a spindle assembly checkpoint (SAC) signal. One outer kinetochore contains a lawn of Ndc80 complexes, resulting in many ...
  7. semanticscholar.org

    It is demonstrated that the Ndc80 loop, a short sequence identified across eukaryotes and predicted to interrupt the NDC80 coiled-coil, promotes direct interactions between full-length N dc80 complexes, suggesting that the organisation of adjacent Ndc 80 complexes is crucial to couple kinetochore-microtubule binding to cell cycle control. During cell division, kinetochores link chromosomes to ...
  8. mpi-dortmund.mpg.de

    Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding. Polley S, Müschenborn H, Terbeck M, De Antoni A, Vetter IR, Dogterom M, Musacchio A, Volkov VA, Huis In 't Veld PJ. EMBO J (2023) Source . During cell division, kinetochores link chromosomes to spindle microtubules. The Ndc80 complex, a crucial microtubule ...
  9. researchgate.net

    The loop also promotes spindle checkpoint signaling, suggesting that the organisation of adjacent Ndc80 complexes is crucial to couple kinetochore-microtubule binding to cell cycle control.
  10. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC10308368

    May 19, 2023These studies postulated that the loop promotes stable kinetochore‐microtubule attachment through the direct binding of microtubule binding proteins such as the Ska complex, CH‐TOG/Stu2, or Cdt1 (Hsu & Toda, 2011; Varma et al, 2012; Zhang et al, 2012, 2017; Tang et al, 2013). Subsequent studies, however, questioned the notion that the loop ...
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