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  1. pubmed.ncbi.nlm.nih.gov

    Here, we investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic elements. Our results show that Myod1 is bound to numerous skeletal muscle enhancers in collaboration with the glucocorticoid receptor (GR) to control gene expression.
    Author:Daniela Rovito, Anna-Isavella Rerra, Vanessa Ueberschlag-Pitiot, Shilpy Joshi, Nezih Karasu, Vanessa...Published:2021
  2. academic.oup.com

    Using chromosome conformation capture on chip (4C) technology, we further show interactions between GR- and Myod1-bound myofiber-specific enhancers and the transcriptionally active promoter regions of glucocorticoid-responsive genes. These interactions take place in GC-rich regions to which the transcription factor Nrf1 is recruited.
    Author:Daniela Rovito, Anna-Isavella Rerra, Vanessa Ueberschlag-Pitiot, Shilpy Joshi, Nezih Karasu, Vanessa...Published:2021
  3. researchgate.net

    Taken together, our data establish Myod1, GR and Nrf1 as key players of muscle-specific enhancer-promoter communication that orchestrate myofiber size regulation. Discover the world's research 25 ...
  4. semanticscholar.org

    The results show that Myod1 is bound to numerous skeletal muscle enhancers in collaboration with the glucocorticoid receptor (GR) to control gene expression, and it is demonstrated that GR negatively controls muscle mass and strength in mice by down-regulating anabolic pathways. Abstract Skeletal muscle is a dynamic tissue the size of which can be remodeled through the concerted actions of ...
  5. pdfs.semanticscholar.org

    manner. Moreover, we demonstrate that GR nega-tively controls muscle mass and strength in mice by down-regulating anabolic pathways. Taken together, our data establish Myod1, GR and Nrf1 as key play-ers of muscle-specific enhancer-promoter communi-cation that orchestrate myofiber size regulation. INTRODUCTION
  6. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › gene › 17927

    Sep 18, 2024Myod1 and GR coordinate myofiber-specific transcriptional enhancers. Inhibition of MEF2c and MyoD expression in the SM of lipin1(Myf5cKO) mice. The on-target pioneer factors Ascl1 and Myod1 are sequence-related, but induce two developmentally unrelated lineages-that is, of neuronal and muscle identities.
  7. ouci.dntb.gov.ua

    Abstract Skeletal muscle is a dynamic tissue the size of which can be remodeled through the concerted actions of various cues. Here, we investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic elements. Our results show that Myod1 is bound to numerous skeletal muscle enhancers in collaboration with the glucocorticoid receptor (GR) to ...
  8. semanticscholar.org

    Myod1 and GR coordinate myofiber-specific transcriptional enhancers. D. Rovito Anna ... 2021; TLDR. The results show that Myod1 is bound to numerous skeletal muscle enhancers in collaboration with the glucocorticoid receptor (GR) to control gene expression, and it is demonstrated that GR negatively controls muscle mass and strength in mice by ...
  9. pubmed.ncbi.nlm.nih.gov

    We propose a model wherein MyoD1 mediates recruitment of Set7, H3K4me1, H3K27ac, p300, and RNAP II to MyoD1-bound enhancers to establish condition-specific activation of muscle genes. Moreover, muscle enhancers are modulated through coordinated binding of transcription factors, including c-Jun, Jdp2, Meis, and Runx1, which are recruited to ...

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