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  1. pubmed.ncbi.nlm.nih.gov

    One of the vaccines deployed worldwide is ChAdOx1 nCoV-19, which uses an adenovirus vector to drive the expression of the original SARS-CoV-2 spike on the surface of transduced cells. Using cryo-electron tomography and subtomogram averaging, we determined the native structures of the vaccine product expressed on cell surfaces in situ .
  2. One of the COVID-19 vaccines granted Emergency Use Licensure by the World Health Organization is AstraZeneca's ChAdOx1 nCoV-19/AZD1222, which is based on a replication-incompetent adenoviral vector. 6 This viral vector enters cells and delivers the gene for the SARS-CoV-2 spike, leading to its transient expression. AZD1222 drives expression of the spike from the Wuhan-Hu-1 strain (GenBank ...
  3. researchgate.net

    ChAdOx1 COVID vaccines e xpress R BD open prefusion SARS-CoV-2 s p ikes on the cell surface Tao Ni 1ǂ # , Luiza Mendonça 1† # , Yanan Zhu 1 # , Andrew Howe 2 , Julika Radecke 2 , Pranav M.
  4. Vaccines against SARS-CoV-2 have been proven to be an effective means of decreasing COVID-19 mortality, hospitalization rates, and transmission. One of the vaccines deployed worldwide is ChAdOx1 nCoV-19, which uses an adenovirus vector to drive the expression of the original SARS-CoV-2 spike on the surface of transduced cells. Using cryo-electron tomography and subtomogram averaging, we ...
  5. We show that ChAdOx1-vectored vaccines expressing the Beta SARS-CoV-2 variant produce abundant native prefusion spikes predominantly in one-RBD-up conformation. Furthermore, the ChAdOx1 vectored HexaPro stabilized spike yields higher cell surface expression, enhanced RBD exposure, and reduced shedding of S1 compared to the wild-type.
  6. sciencedirect.com

    To understand what conformation(s) the vaccine spikes adopt on transduced U2OS cell surfaces, we collected cryo-electron tomography (cryo-ET) tilt-series to image the cell periphery (Figure S2; Table S1).As shown in representative tomograms (Figure 2 A and Videos S1 and S2), a remarkably high amount of spike protein is seen on the cell surface, as seen by the club-head shapes in the side view ...
  7. immunology.ox.ac.uk

    Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been proven to be an effective means of decreasing COVID-19 mortality, hospitalization rates, and transmission. One of the vaccines deployed worldwide is ChAdOx1 nCoV-19, which uses an adenovirus vector to drive the expression of the original SARS-CoV-2 spike on the surface of transduced cells. Using cryo ...
  8. iScience Article ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface Tao Ni, 1,7 9Luiza Mendonc¸a, 8 Yanan Zhu,1,9 Andrew Howe,2 Julika Radecke,2 Pranav M. Shah, 3 Yuewen Sheng,2 Anna-Sophia Krebs,1 Helen M.E. Duyvesteyn,1 Elizabeth Allen,4 Teresa Lambe,4,5 Cameron Bisset, 4Alexandra Spencer, Susan Morris,6 David I. Stuart,1 ,2 3 6 Sarah Gilbert,4 ,5 6
  9. ncbi.nlm.nih.gov

    Expression of prefusion conformation SARS-CoV-2 S glycoprotein on cell surfaces upon ChAdOx1 nCoV-19 infection. ChAdOx1 nCoV-19 encodes a wild-type S sequence, including the transmembrane domains, which is trafficked to the cell surface with a tissue plasminogen activator (tPA) signal sequence (Fig. 1A).Using flow cytometry, we first detected the presence of the S glycoprotein at the cell ...

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