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  1. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC5451211

    Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown. Using acute inactivation approaches and live-cell imaging in Drosophila embryos, we dissect the role of condensin I in the maintenance of mitotic chromosome structure with unprecedented temporal resolution. Removal of condensin I ...
    Publication:eLife. 2017; 6: e26120.Author:Ewa Piskadlo, Alexandra Tavares, Raquel A OliveiraPublished:2017
  2. elifesciences.org

    To study the role of condensin complexes in the maintenance of chromosome structure, specifically during metaphase, we developed a system to enable analysis of chromosomal structural changes upon rapid and temporally controlled inactivation of condensin in Drosophila melanogaster.Our analysis focused on condensin I complex as prior studies reveal a minor role for condensin II in mitotic ...
    Author:Ewa Piskadlo, Alexandra Tavares, Raquel A OliveiraPublished:2017
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  4. researchgate.net

    The condensin complex is a key determinant of mitotic chromosome architecture. In addition, condensin promotes resolution of sister chromatids during anaphase, a function that is conserved from ...
  5. semanticscholar.org

    It is proposed that maintenance of chromosome resolution is a highly dynamic bidirectional process that is capable of re-intertwining previously separated DNA molecules and condensin I continuously required to counteract this erroneous activity. Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic ...
  6. Maintenance of metaphase chromosome architecture by condensin I: Author: Piskadto, Ewa: Keywords: Metaphase Chromosome: Defense Date: 2017: Abstract: "Faithful segregation of the genome into two daughter cells is one of the most fundamental events for every living organism.
  7. The condensin complex is a key determinant of mitotic chromosome formation. Thadani et al. study the dynamic binding of condensin to chromosomes. They reveal how condensin turnover is regulated by its ATPase and by cell-cycle phosphorylation. Chromosome condensation in mitosis requires fine-tuning of this dynamic behavior.
  8. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC452584

    Two different condensin complexes make distinct contributions to metaphase chromosome architecture in vertebrate cells. We show here that the spatial and temporal distributions of condensins I and II are differentially regulated during the cell cycle ...
  9. cdn.elifesciences.org

    Metaphase chromosome structure is ... Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown. Using acute inactivation approaches and live-cell imaging in Drosophila embryos, we dissect the role of condensin I in the maintenance of mitotic chromosome structure with unprecedented
  10. pubmed.ncbi.nlm.nih.gov

    Jun 10, 2024Structural maintenance of chromosomes (SMC), including cohesin, condensin and the SMC5/6 complex, are protein complexes which maintain the higher structure and dynamic stability of chromatin. Such circular complexes, with similar structures, play pivotal roles in chromatid cohesion, chromosomal condensation, DNA replication and repair, as well ...

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