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  1. cordis.europa.eu

    In native tissues, the extracellular matrix (ECM) provides not only physical scaffolding to cells, but also biochemical and biomechanical cues affecting cell behaviour. ECM mechanical properties are critical in the regulation of cell behaviour during tissue development...
  2. In recent years, energy dissipation causing time-dependent relaxation of substrates under strain has been observed to influence cell behavior too (11, 12).Since the ECM is not an elastic but a viscoelastic material showing remarkable viscous energy dissipation (), there is a fundamental interest in understanding the mechanisms by which the viscoelastic properties of the ECM are sensed by cells ...
  3. pubs.acs.org

    The extracellular matrix (ECM) performs both as a static scaffold and as a dynamic, viscoelastic milieu that actively participates in cell signaling and mechanical feedback loops. Recently, biomaterials with tunable viscoelastic properties have been utilized to mimic the native ECM in the fields of tissue engineering and regenerative medicines. These materials can be designed to support cell ...
  4. sciencedirect.com

    The viscoelasticity of the ECM is of great importance for the cells, ... This allowed the authors to study cell response towards this dynamic change in nanotopography [30]. ... a perspective on material-guided cell behaviors and tissue engineering. Chem. Rev., 117 (2017), pp. 4376-4421. Crossref View in Scopus Google Scholar
  5. pubs.acs.org

    fibrosis or cancer. The study of biomaterial viscoelasticity thus intersects with a broad spectrum of biological and medical disciplines, offeringinsights into fundamental cell biology and practical solutions for improving human health. This review delves into the design and fabrication strategies of viscoelastic hydrogels, focusing
  6. ncbi.nlm.nih.gov

    Therefore, research in this field has gradually shifted from studying static biomaterials to materials with dynamic mechanical properties. The development of dynamic hydrogels (viscoelasticity and dynamic stiffness) to mimic native 3D cellular microenvironments and study their regulation of cellular behavior is of significant importance.
  7. ncbi.nlm.nih.gov

    In this study, we describe a novel method for engineering cell culture substrates able to mimic dynamic, time-evolving viscoelastic transitions during culture. In particular, a two-step crosslinking procedure was employed to modulate the mechanical behaviour of gelatin hydrogels, which are typically used as a cell culture substrates . The ...
  8. design and control over key cell-instructive properties. Herein, we report a class of fully synthetic hydrogels based on novel DNA libraries that self-assemble with ultra-high molecular weight polymers, forming a dynamic DNA-crosslinked matrix (DyNAtrix). DyNAtrix enables, for the first time, computationally predictable, systematic, and ...

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