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  1. sciencedirect.com

    This review aims to provide an in-depth discussion on various nanosystems for nucleic acid delivery and therapeutics. They offer a powerful approach to address the limitations of traditional treatments, and hence can potentially overcome these challenges.
  2. pubs.rsc.org

    Aug 7, 2024This review emphasized various nucleic acid-based therapeutics and their enhanced and improved delivery using different nanocarriers. Ultimately, the importance of lipid-based nanocarriers for delivering NAs is discussed and provides perspective in this field.
  3. pmc.ncbi.nlm.nih.gov

    Nov 22, 2024Engineering nanomaterials to deliver biological molecules to exert desirable physiological changes, with minimized side effects and optimal dose, has revolutionized the next-generation therapy for several diseases. The rapid progress of nucleic acids as biopharmaceutics is going to alter the traditional pharmaceutics practices in modern medicine.
  4. sciencedirect.com

    Mar 1, 2024In this review, we highlight progress made in the use of non-viral protein-based nanoparticles for nucleic acid delivery in vitro and in vivo, while elaborating on key physicochemical properties that have enabled the use of these materials for nanoparticle formulation and drug delivery.
  5. sciencedirect.com

    Nowadays, nucleic acid-based self-assembling nanocarriers (NASNs) play an increasingly greater role in the research and development in biomedical studies, particularly in drug delivery, release and targeting. In this review, NASNs are systematically summarized the strategies cooperated with their broad applications in drug delivery.
  6. thelancet.com

    1 day agoThe blood-brain barrier is a physiological barrier that can prevent both small and complex drugs from reaching the brain to exert a pharmacological effect. For treatment of neurological diseases, drug concentrations at the target site are a fundamental parameter for therapeutic effect; thus, the blood-brain barrier is a major obstacle to overcome. Novel strategies have been developed to ...
  7. Dec 31, 2024TL;DR: Recent advancements in nanosystems enhance nucleic acid delivery for treating viral infections, neurological disorders, genetic diseases, and metabolic disorders, leveraging plasmid DNA, siRNA, and other NAs as therapeutic agents.
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