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  1. pmc.ncbi.nlm.nih.gov

    This makes inference of whether FABP4 is causal to CVD challenging as collider bias, where FABP4 (exposure) and cardiovascular disease (outcome) are both influenced by other factors, may muddy the water [100, 101]. Additional research should focus on specific at-risk subgroups and apply strategies to address collider bias by other factors—in ...
    • The Effects of FABP4 on Cardiovascular Disease in the Aging Population

      Elevated FABP4 levels indicate an increased cardiovascular risk and is causally related to acceleration of atherosclerotic disease, However, clinical trials for FABP4 inhibition are lacking, possibly due to concerns about available compounds' side effects. Further research on FABP4 genetics and its putative causal role in cardiovascular disease ...

  2. pubmed.ncbi.nlm.nih.gov

    May 3, 2024Elevated FABP4 levels indicate an increased cardiovascular risk and is causally related to acceleration of atherosclerotic disease, However, clinical trials for FABP4 inhibition are lacking, possibly due to concerns about available compounds' side effects. Further research on FABP4 genetics and its putative causal role in cardiovascular disease ...
  3. link.springer.com

    May 3, 2024Purpose of Review Fatty acid-binding protein 4 (FABP4) plays a role in lipid metabolism and cardiovascular health. In this paper, we cover FABP4 biology, its implications in atherosclerosis from observational studies, genetic factors affecting FABP4 serum levels, and ongoing drug development to target FABP4 and offer insights into future FABP4 research. Recent Findings FABP4 impacts cells ...
  4. link.springer.com

    May 4, 2024The Effects of FABP4 on Cardiovascular Disease in the Aging Population Ellen M. van der Ark‑Vonk1 · Mike V. Puijk1 · Gerard Pasterkamp1 · Sander W. van der Laan1 Accepted: 5 March 2024 / Published online: 3 May 2024 ... cal impact of (fatal) atherosclerosis in an aging population and the recognition that more work in the decades to follow ...
  5. pmc.ncbi.nlm.nih.gov

    Circulating FABP4 levels are associated with several aspects of metabolic syndrome and cardiovascular disease. Ectopic expression and function of FABP4 in cells and tissues are also related to the pathogenesis of several diseases. ... The concentration of FABP4 is highest among levels of FABP1∼5 under a physiological condition in a general ...
  6. ahajournals.org

    In the Cardiovascular Health Study, we measured FABP 4 levels in stored specimens from the 1992-993 visit and followed participants for incident CVD if they were free of prevalent CVD at baseline and for CVD mortality through June 2015. We used Cox regression to estimate hazard ratios for incident CVD and CVD mortality per doubling in serum FABP ‐4 adjusted for age, sex, race, field center ...
  7. semanticscholar.org

    May 3, 2024Elevated FABP4 levels indicate an increased cardiovascular risk and is causally related to acceleration of atherosclerotic disease, However, clinical trials for FABP4 inhibition are lacking, possibly due to concerns about available compounds' side effects. Purpose of Review Fatty acid-binding protein 4 (FABP4) plays a role in lipid metabolism and cardiovascular health. In this paper, we ...
  8. pubmed.ncbi.nlm.nih.gov

    Background FABP-4 (fatty acid binding protein-4) is a lipid chaperone in adipocytes and has been associated with prognosis in selected clinical populations. We investigated the associations between circulating FABP-4, risk of incident cardiovascular disease (CVD), and risk of CVD mortality among old …
  9. researchinformation.umcutrecht.nl

    FABP4 is established as a reliable predictive biomarker for cardiovascular disease in specific at-risk groups. Genetic studies robustly link PPARG and FABP4 variants to FABP4 serum levels. Considering the potential effects on atherosclerotic lesion development, drug discovery programs have been initiated in search for potent inhibitors of FABP4.
  10. discovery.researcher.life

    May 1, 2024Article on The Effects of FABP4 on Cardiovascular Disease in the Aging Population, published in Current atherosclerosis reports 26 on 2024-05-01 by Ellen M Van Der Ark-Vonk+3. Read the article The Effects of FABP4 on Cardiovascular Disease in the Aging Population on R Discovery, your go-to avenue for effective literature search.
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