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  1. neurology.org

    Mar 21, 2024We read with great interest the report by Moehlman et al., which emphasizes that cerebellitis is a rare manifestation of anti-NMDA receptor encephalitis (NMDAR) in pediatric patients. 1 Although the brain MRI only revealed a left cerebellar lesion, the child's symptoms of seizures and behavioral/speech regression suggested possible damage to the cerebral cortex.
  2. neurology.org

    This is an illustrative Teaching NeuroImage with a great central message. 1 As mentioned in the case, pachymeningeal enhancement (PE) in anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE) is not common in clinical practice. In a Mexican tertiary referral center, only 7.5% (n=6; 5 women; median age: 18.5 years, IQR: 28.5 years) of those with ANMDARE had PE in a 7-year period. 2 MRI was ...
  3. neurology.org

    The frequently reported abnormalities on MRI in anti-NMDAR encephalitis are lep-tomeningeal enhancement and T2/FLAIR cortical and subcortical hyperintensities in the temporal lobe, followed by the frontal lobe, periventricular region, and cerebellum, rarely involving the dura mater.1,2 Study Funding No targeted funding reported. Disclosure
  4. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC4558461

    Introduction. Anti-N-methyl-d-aspartate receptor (NMDA-R) antibody encephalitis was discovered in 2007 in several females with ovarian teratoma presenting with psychiatric and dys-autonomous symptoms.The disease has also been described in the paediatric population. It is an autoimmune disease with auto-antibodies targeting the NMDA-R (Dalmau et al., 2011).
    Publication:Neuroimage. 2015 Sep; 118: 508-519.Author:Gerald K. Cooray, Gerald K. Cooray, Biswa Sengupta, Pamela K. Douglas, Marita Englund, Ronny Wickstr...Published:2015
  5. sciencedirect.com

    Plasticity of synaptic strength and density is a vital mechanism enabling memory consolidation, learning, and neurodevelopment. It is strongly dependent on the intact function of N-Methyl-d-Aspartate Receptors (NMDAR).The importance of NMDAR is further evident as their dysfunction is involved in many diseases such as schizophrenia, Alzheimer's disease, neurodevelopmental disorders, and epilepsies.
  6. academic.oup.com

    Spectral characteristics of NMDAR-antibody encephalitis. (A) Left: EEG, scalp data from mid-frontal channel Fz from exemplar patients in each group.Right: Though NMDAR-antibody encephalitis can present with a range of clinical and electrographic features there was no statistical difference in the clinical severity of encephalopathy (West-Haven scale) applied to the two groups.
  7. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC6196513

    We first model the NMDAR-Ab effect in the mouse model using DCM to identify a minimal set of synaptic parameters required to produce the NMDAR-Ab effects on ongoing neuronal oscillations. Based on patient EEG data, we then estimate fluctuations in the parameters that explain the patient recordings. ... Neuroimage. 2015; 108:460-475. [PMC free ...
  8. pubmed.ncbi.nlm.nih.gov

    Plasticity of synaptic strength and density is a vital mechanism enabling memory consolidation, learning, and neurodevelopment. It is strongly dependent on the intact function of N-Methyl-d-Aspartate Receptors (NMDAR). The importance of NMDAR is further evident as their dysfunction is involved in ma …
  9. onlinelibrary.wiley.com

    Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis shows a predilection for affecting the limbic system, but structural MRI in most patients is usually unremarkable.However, the functional connectivity reorganization of limbic nodes remains unknown. Serum neurofilament light chains (sNfL) are clinically linked with the disease severity and neurological disability of anti-NMDAR encephalitis.
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