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  1. organvision.eu

    Christoph Manthey, "Stem cell-derived engineered heart tissue develops in the absence of contractility" presented at the Annual Meeting of the German Cardiac Society, Mannheim, Germany, 2023 Rajiven Srikantharajah, "Engineered heart tissue with a pharmacological off-switch as a tool to study the influence of cardiac work on cardiomyocyte ...
  2. pubmed.ncbi.nlm.nih.gov

    Here we aim at providing a concise but comprehensive overview of the perspectives and challenges of heart repair with pluripotent stem cell-derived cardiomyocytes. This Review comes at a time when consensus has been reached about the lack of relevant proliferative capacity of adult mammalian cardiomyocytes and the lack of new heart muscle ...
  3. pmc.ncbi.nlm.nih.gov

    Bartunek J, Dimmeler S, Drexler H, et al. The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur Heart J. 2006;27:1338-1340. doi: 10.1093/eurheartj/ehi793. [Google Scholar]
  4. pmc.ncbi.nlm.nih.gov

    These mechanistic insights will be critical for the development of new strategies to overcome the obstacles in cell‐based cardiac repair, which is of great importance for moving the cell therapy and cell‐free therapy toward clinical transplantation. ... for cell reprogramming and heart repair: progress and perspective. ACS Chem Biol. 2014;9 ...
  5. pmc.ncbi.nlm.nih.gov

    Finally, stem cell therapy needs to be safe, reproducible, and affordable. In this review, we will give an introduction to the principles of stem cell based cardiac repair. Keywords: Stem cell, Regeneration, Heart, Cardiomyocytes. 1. Introduction. Repairing the injured body with its own tissue as a substrate has captured human fascination for a ...
  6. cdnsciencepub.com

    Jan 16, 2024Stem cell therapy has shown promise for cardiac regeneration and repair. However, for clinical translation of stem cell-based approaches, the above-described challenges need to be addressed. The heterogeneity of stem cell isolation and culture procedures can be addressed by standardizing the media components being used for each stem cell type.
  7. thelancet.com

    Despite advances in cardiovascular biology and medical therapy, heart disorders are the leading cause of death worldwide. Cell-based regenerative therapies become a promising treatment for patients affected by heart failure, but also underline the need for reproducible results in preclinical and clinical studies for safety and efficacy. Enthusiasm has been tempered by poor engraftment ...
  8. Breakthroughs in stem cell biology in the 1990s and 2000s led to the hypothesis that heart muscle cells (cardiomyocytes) could be regenerated by transplanting stem cells or their derivatives. It has been ∼18 years since the first clinical trials of stem cell therapy for heart repair were initiated ( 1 ), mostly using adult cells.
  9. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC3362797

    Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) Human embryonic stem cells, isolated from the inner cell mass of blastocyst, can self-renew while maintaining their pluripotency to differentiate into all cell types 5, including CMs 6-7.Therefore, in principle, hESCs can serve as an unlimited ex vivo source of CMs for cell-based heart therapies.
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