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Showing results excluding:
  • cordis.europa.eu

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  1. Fellows Bhavya Ojha obtained her BSc in Neuroscience from Dalhousie University, Canada, and an MSc in Molecular bioscience (majors: Neuroscience) from Heidelberg University, Germany. Her MSc thesis focused on impact of chronic neuropathic pain on attention in mice. In the PMSMatTrain project, her research focuses on progressive multiple sclerosis and assessing potential therapy delivered via ...
  2. dementianetwork.ie

    PMSMatTrain focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs). The consortium will develop a multi-modal "tuneable" hydrogel-based medical device designed to bring about biphasic release of anti-inflammatory molecules and ...
  3. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC8911110

    Therefore, a single molecular marker is unlikely to exist, and efforts on molecular research in multiple sclerosis should be made towards integrating analytic approaches, including clinical characteristics, MRI variables and proteins, and metabolite concentrations to create signatures of MS disease diagnosis, prognosis, and treatment response.
  4. pmc.ncbi.nlm.nih.gov

    Still, there are some MS therapeutics, including copaxon and natalizumab, the development of which has been based on EAE studies (460). Importantly, numerous molecular and cellular mechanisms of MS pathogenesis have been discovered in EAE research (36, 91, 251, 460).
  5. pubmed.ncbi.nlm.nih.gov

    Therefore, using multiple sclerosis (MS) as an example of a complex polygenic neurological disease, we sought to determine whether cerebrospinal fluid (CSF) biomarkers are intraindividually stable, cell type-, disease- and/or process-specific, and responsive to therapeutic intervention.
  6. The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated and progressive disability. Disease mechanisms can be investigated in preclinical models and patients with multiple sclerosis by molecular and metabolic imaging techniques. Many insights have been gained from such imaging studies: persisting inflammation in the absence of a ...
  7. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC10342392

    Jun 26, 2023Multiple sclerosis (MS) is a chronic autoimmune disease that impacts the central nervous system and can result in disability. Although the prevalence of MS has increased in India, diagnosis and treatment continue to be difficult due to several factors. The present study examines the difficulties in detecting and treating multiple sclerosis in ...

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