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Showing results excluding:
  • www.ncbi.nlm.nih.gov

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  1. Currently, systemic delivery of drugs for PMS is limited by the inability of drugs to cross the blood-brain barrier (BBB). The PMSMatTrain project will develop new technology that allows controlled and targeted delivery of therapeutic molecules directly to the brain cortical tissue, exploiting "tuneable" biomaterials that allow a multi-phasic delivery of therapeutics from a minimally ...
  2. PMSMatTrain focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs). ... 15 Early Stage Researchers in functionalised biomaterials, materials science, stem cell biology, pre-clinical models ...
  3. Bhavya Ojha obtained her BSc in Neuroscience from Dalhousie University, Canada, and an MSc in Molecular bioscience (majors: Neuroscience) from Heidelberg University, Germany.Her MSc thesis focused on impact of chronic neuropathic pain on attention in mice. In the PMSMatTrain project, her research focuses on progressive multiple sclerosis and assessing potential therapy delivered via novel routes.
  4. curamdevices.ie

    Novel Biomaterial-based Device for the Treatment of Progressive MS. An Integrated Pan-European Approach ‌‌‌ Overview of the Programme . PMSMatTrain focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs).
  5. dementianetwork.ie

    PMSMatTrain focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs). ... stem cell biology, in vitro & pre-clinical models, molecular biology, in silico modelling, functionalisation strategies ...
  6. pmc.ncbi.nlm.nih.gov

    Importantly, numerous molecular and cellular mechanisms of MS pathogenesis have been discovered in EAE research (36, 91, 251, 460). New EAE variants are also emerging, and they are exploring aspects of MS that were previously unaddressed in animal models, for example, the role of CD8 + T cells in neuroinflammation ( 14 , 225 ).
  7. cordis.europa.eu

    Oct 28, 2024Brain Proteomic Signatures of an in vivo Model ofMultiple Sclerosis. Author(s): M. Fucito, B. Ojha, R. Khorooshi, T. Owens, A. Nawrocki, M. Røssel Larsen, P. del Boccio, D.Pieragostino Published in: Proteomic Forum EuPA Abstract Booklet, 2022 Publisher: EuPA Longitudinal evaluation of the therapeutic effect of APRIL in the Cuprizone mouse model of Multiple Sclerosis
  8. pubmed.ncbi.nlm.nih.gov

    Therefore, using multiple sclerosis (MS) as an example of a complex polygenic neurological disease, we sought to determine whether cerebrospinal fluid (CSF) biomarkers are intraindividually stable, cell type-, disease- and/or process-specific, and responsive to therapeutic intervention.
  9. pubmed.ncbi.nlm.nih.gov

    Sep 15, 2023Background: Multiple sclerosis (MS), a chronic inflammatory disorder, affects the central nervous system via myelin degradation. The cause of MS is not fully known, but during recent years, our knowledge has deepened significantly regarding the different aspects of MS, including etiology, molecular pathophysiology, diagnosis and therapeutic options.

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