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  1. Only showing results from www.ncbi.nlm.nih.gov

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  2. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC8911110

    Therefore, a single molecular marker is unlikely to exist, and efforts on molecular research in multiple sclerosis should be made towards integrating analytic approaches, including clinical characteristics, MRI variables and proteins, and metabolite concentrations to create signatures of MS disease diagnosis, prognosis, and treatment response.
  3. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC5743213

    Complex neurological disorders such as multiple sclerosis (MS) are generally treated by a single disease modifying treatment (DMT), without understanding patient-specific drivers of disability. The multiplicity of mechanisms in neurodegenerative diseases and heterogeneity within patient populations makes successful treatment by a single therapy ...
    Author:Christopher Barbour, Peter Kosa, Mika Komori, Makoto Tanigawa, Ruturaj Masvekar, Tianxia Wu, Kory Jo...Published:2017
  4. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC7547375

    Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), caused by genetic and environmental factors. It is characterized by intermittent and recurrent episodes of inflammation that result in the demyelination and subsequent damage of the underlying axons present in the brain, optic nerve and spinal ...
    Author:Maryam Gul, Amirhossein Azari Jafari, Muffaqam Shah, Seyyedmohammadsadeq Mirmoeeni, Safee Ullah Haid...Published:2020
  5. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC10342392

    Jun 26, 2023Multiple sclerosis (MS) is a chronic autoimmune disease that impacts the central nervous system and can result in disability. Although the prevalence of MS has increased in India, diagnosis and treatment continue to be difficult due to several factors. The present study examines the difficulties in detecting and treating multiple sclerosis in ...
  6. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC7287961

    1. Introduction. Multiple sclerosis (MS) is the commonest inflammatory autoimmune disorder of the central nervous system (CNS), progressively leading to demyelination, neurodegeneration, and neuronal disability [1,2,3].MS globally affects more than 2.5 million people and it often afflicts young people, mainly women [4,5].Despite the availability of a large arsenal of putative therapeutic ...
  7. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC10481116

    Aug 17, 2023Multiple molecular pathways are involved in the pathogenesis of the disease. The present review showcases the recent advancements in harnessing nature's resources to combat MS. By deciphering the molecular pathways involved in the pathogenesis of the disease, a wealth of potential therapeutic agents is uncovered that may revolutionize the ...
  8. ncbi.nlm.nih.gov

    The treatment of multiple sclerosis has been radically transformed over the past 20 years and this special issue of IJMS, focusing on the molecular aspects of the disease, highlights the growing conformity of the various investigative approaches. It is a very exciting time to be involved in the research of this disease.
  9. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC8072148

    The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great challenge. This study aimed to investigate the pathogenesis and potential therapeutic targets of MS and to define target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophorae flavescens that effectively suppressed experimental autoimmune encephalomyelitis (EAE), an ...
  10. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC9744737

    These CSF proteins can be aggregated into molecular diagnostic test of multiple sclerosis (MS) 3 that outperforms magnetic resonance imaging (MRI)-based diagnosis of MS (i.e., independent cohort-validated area under receiver-operator characteristic curve (AUROC) 0.98 for the molecular diagnostic test 3 versus AUROC of ~0.70 for the MRI-based ...
  11. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC3497294

    1. Introduction. Multiple sclerosis (MS) is a chronic, progressive, inflammatory disease affecting the central nervous system (CNS). Jean-Martin Charcot is generally credited with the first comprehensive clinical description of MS following his treatise "le sclerose en plaques" in 1868 [].Charcot identified patients who had discrete episodes of neurological dysfunction associated with ...

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