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  1. Jul 11, 2024Drug delivery is essential to provide correct treatments in many ways. The critical points in any drug delivery method are patient compliance, maximum efficacy in therapy, minimum toxicity, and enabling new medical treatments. Pulmonary drug delivery is one way of delivering therapeutics locally and systemically. The lung microenvironment and mechanical and biological barriers must be ...
  2. pharmaexcipients.com

    1.3. Formulations and Materials in Pulmonary Delivery Pulmonary delivery is an evolving field in therapeutics, but it is also quite challenging. The anatomy and physiology of the lung are demanding and challenging and must be taken care of before designing specific formulations for drug delivery. Carriers at the nanoscale
  3. pmc.ncbi.nlm.nih.gov

    The HNPs released from the spray dried composites retained their responsive behavior thereby illustrating the potential for these materials as intelligent drug delivery systems that combine the advantages of nanotechnology, lung targeting through pulmonary delivery, and stimuli-responsive hydrogels.
  4. semanticscholar.org

    This review has gathered fundamental studies related to materials that are responsive to pH, enzymes, ROS, magnetism, and other variables, and it shows the advances and applications in pulmonary drug delivery for different diseases in vitro as well as in vivo. Drug delivery is essential to provide correct treatments in many ways. The critical points in any drug delivery method are patient ...
  5. pmc.ncbi.nlm.nih.gov

    Schematic representation of compressive, tensile, and shear forces. While there are relatively few reports of mechanoresponsive drug delivery systems [], they cover the breadth of mechanical forces: compression, tension, and shear.Mechanoresponsive drug delivery is attractive due to the ease of applying compressive, tensile, and shear stimuli, and to the ubiquity of these forces in the human body.
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  7. pmc.ncbi.nlm.nih.gov

    Stimuli-responsive drug delivery systems (DDSs) offer precise control over drug release, enhancing therapeutic efficacy and minimizing side effects. This review focuses on DDSs that leverage the unique capabilities of phase change materials (PCMs) and metal-organic frameworks (MOFs) to achieve controlled drug release in response to pH and ...
  8. link.springer.com

    Jun 15, 2023Hydrogels and hydrogel-based materials are promising delivery cargos with good potential ranging from drug delivery, drug targeting to diagnostic applications [49, 50].Particularly in drug delivery, hydrogels are explored to carry a variety of therapeutic moieties ranging from low molecular weight molecules to macromolecular substances [51, 52]. ...
  9. sciencedirect.com

    Drug Delivery Experiments A schematic of the electric field responsive controlled drug delivery is shown in Fig. 5. Hematoxylin was selected as model of hydrophilic drug. Hematoxylin is a chromophore with a maximum absorbance at 560nm, therefore release from the hydrogel polymer matrix can be easily monitored using UV-visible spectroscopy.
  10. sciencedirect.com

    There are numerous advantages of the pulmonary drug delivery that can be attributed to the physiology and anatomical features of the lungs [10].The large surface area (100-120 cm 2), abundant blood supply, and thin epithelial lining (0.5-0.7 μm) are some features of the lungs that make them an ideal site for absorption drugs [4], [11].In addition to these features, a tendency to avoid the ...
  11. researchgate.net

    Jul 11, 2024Pulmonary Drug Delivery through Responsive Materials Nikolaos Politakos 1, * , V asilis G. Gregoriou 1,2 and Christos L. Chochos 1,2 1 Institute of Chemical Biology , National Hellenic Research ...

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