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  1. The ultimate aim of RECOMB is to create a novel treatment for one of the most common types of SCID, RAG1-SCID by performing phase 1 and phase 2 clinical trials using autologous haematopoietic stem cell‒based gene therapy. SCID comprises a group of rare diseases in which cells in the adaptive immune system fail to develop properly.
    • RECOMB Webinar: GENE THERAPY for RAG1-SCID

      The very first RECOMB webinar takes place on January 29, 15 CET and will introduce gene therapy for recombination-deficient severe combined immunodeficiency (RAG-SCID) and discuss how it will work for RAG1-SCID. It will also provide the latest status report and prospects of the project.

    • RECOMB

      The ultimate aim of RECOMB is to create a treatment for the most common type of SCID, RAG1-SCID by performing phase 1 and phase 2 clinical trials using autologous haematopoietic stem cell‒based gene therapy.

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  3. cordis.europa.eu

    Nov 4, 2024Stem-cell based gene therapy for recombination deficient SCID (RECOMB) Results. Fact Sheet Reporting Results Fact Sheet Reporting Results Project Information RECOMB. Grant agreement ID: 755170 Open in new window. DOI 10.3030/755170. EC signature date 21 November ...
  4. cordis.europa.eu

    As allo-SCT is still facing limitations, there is an urgent need for new therapies based on the genetic correction of autologous stem cells where the patient's own cells are modified and transplanted back. Recomb is a research consortium developing stem cell-based gene therapy (GT) as a life-saving alternative for RAG1-SCID patients.
  5. healtheuropa.com

    Recomb is a multinational research consortium working to develop autologous stem cell-based GT as a curative treatment for recombination-deficient severe combined immunodeficiency. GT aims to cure disease by delivering the therapeutic gene into the target cells using vectors to restore the production and function of the wild-type protein.
  6. The very first RECOMB webinar takes place on January 29, 15 CET and will introduce gene therapy for recombination-deficient severe combined immunodeficiency (RAG-SCID) and discuss how it will work for RAG1-SCID. It will also provide the latest status report and prospects of the project.
  7. cordis.europa.eu

    Nov 4, 2024Gene therapy for rare inherited immune disorders has become a clinical reality. Especially for SCID, two major types of SCID (ADA-SCID, X-SCID) have been successfully treated by autologous stem cell based gene therapy. However, for the most common group of SCID, the SCID...
  8. confined to allogeneic hematopoietic stem cell transplantation (HSCT)2 ,3 and autologous stem cell gene therapy (GT).45 More than 20 different genes have been shown to be causative for SCID.1 Three major types of SCID exist, which include the common g-chain cytokine deficiencies, mainly due to defects in the IL2R
  9. complicitymap.eu

    Stem-cell based gene therapy for recombination deficient SCID (RECOMB) New therapies for rare diseases (SC1-PM-08-2017) ... two major types of SCID (ADA-SCID, X-SCID) have been successfully treated by autologous stem cell based gene therapy. However, for the most common group of SCID, the SCID underlying recombination defects, this has not yet ...

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