Always private
DuckDuckGo never tracks your searches.
Learn More
You can hide this reminder in Search Settings
All regions
Argentina
Australia
Austria
Belgium (fr)
Belgium (nl)
Brazil
Bulgaria
Canada (en)
Canada (fr)
Catalonia
Chile
China
Colombia
Croatia
Czech Republic
Denmark
Estonia
Finland
France
Germany
Greece
Hong Kong
Hungary
Iceland
India (en)
Indonesia (en)
Ireland
Israel (en)
Italy
Japan
Korea
Latvia
Lithuania
Malaysia (en)
Mexico
Netherlands
New Zealand
Norway
Pakistan (en)
Peru
Philippines (en)
Poland
Portugal
Romania
Russia
Saudi Arabia
Singapore
Slovakia
Slovenia
South Africa
Spain (ca)
Spain (es)
Sweden
Switzerland (de)
Switzerland (fr)
Taiwan
Thailand (en)
Turkey
Ukraine
United Kingdom
US (English)
US (Spanish)
Vietnam (en)
Safe search: moderate
Strict
Moderate
Off
Any time
Any time
Past day
Past week
Past month
Past year
  1. cordis.europa.eu

    Latest report summary
    • HIV-1 sensing and signaling in dendritic cells - CORDIS

      It has long been believed that HIV-1 is able to cause immune dysfunction by evading innate sensing in specific immune cells called dendritic cells. SENTINEL project researchers, however, discovered that the virus does not evade the innate sensing mechanism but instead actively suppresses it.

  2. Was this helpful?
  3. cordis.europa.eu

    It has long been believed that HIV-1 is able to cause immune dysfunction by evading innate sensing in specific immune cells called dendritic cells. SENTINEL project researchers, however, discovered that the virus does not evade the innate sensing mechanism but instead actively suppresses it.
  4. pmc.ncbi.nlm.nih.gov

    Turville SG, et al. Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol. 2002;3:975-983. doi: 10.1038/ni841. [Google Scholar] 4. Lambert AA, et al. The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways.
  5. pmc.ncbi.nlm.nih.gov

    Abstract. HIV-1-specific antibodies and CD8 + cytotoxic T cells are detected in most HIV-1-infected people. Yet, HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus unable to effectively prime naïve, HIV-1-specific T cells.
  6. pubmed.ncbi.nlm.nih.gov

    Here, we summarize current knowledge of the molecular basis for sensing HIV-1 in human cells, including CD4 + T cells, dendritic cells, and macrophages. Furthermore, we discuss the underlying mechanisms by which innate sensing is regulated, and describe the strategies developed by HIV-1 to evade sensing and immune responses.
    Author:Xin Yin, Simon Langer, Simon Langer, Zeli Zhang, Zeli Zhang, Kristina M. Herbert, Sunnie Yoh, Renate...Published:2020
  7. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC5346539

    Dendritic Cell Response to HIV-1 Is Controlled by Differentiation Programs in the Cells and Strain-Specific Properties of the Virus ... of the two functionally different DC lineages might indicate fundamental differences in the HIV-activated receptors and signaling processes. Nevertheless, HIV-1 induced a modest but consistent IL-6 and IL-10 ...
  8. HIV-1-specific antibodies and CD8+ cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent ...
  9. globaloncmap.org

    Current paradigm suggests that HIV-1 evades innate sensing in dendritic cells and that this underlies immune dysfunction. However, our innovative data demonstrate that HIV-1 actively suppresses a novel innate sensing mechanism and antagonizing this HIV-1 suppression by drugs strongly enhanced antiviral immunity.
  10. pubmed.ncbi.nlm.nih.gov

    Purpose of review: This review summarizes the current knowledge of innate signaling events that are involved in HIV-1 infection. We here focus on dendritic cells, which are among the first cells that encounter HIV-1 after exposure. Recent findings: HIV-1 triggers multiple pattern recognition receptors on dendritic cells that facilitate infection and transmission to T cells.
  11. Can’t find what you’re looking for?

    Help us improve DuckDuckGo searches with your feedback

Custom date rangeX