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  1. The mechanical sounds of robots and the electronic hum of computers are features of 21st-century life. Despite the joys of increasing automation, simple experiments still produce wonderful new discoveries in molecular biology. The realization several years ago that double-stranded RNA (dsRNA) is a key player in one form of posttranscriptional gene silencing indicated that a new field of great ...
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  3. These observations lead to a model for regulation of gene expression in which the formation of repetitive RNA-RNA duplexes controls the production of messenger RNA. ... SMITH, M.J., REPETITIVE AND NON-REPETITIVE SEQUENCE IN SEA-URCHIN HETEROGENEOUS NUCLEAR-RNA, JOURNAL OF MOLECULAR BIOLOGY 85: 103 ... Gene Expression in Eukaryotes, Science, 211 ...
    Author:Eric H. Davidson, Roy J. BrittenPublished:1979
  4. pmc.ncbi.nlm.nih.gov

    Small RNA molecules regulate eukaryotic gene expression during development and in response to stresses including viral infection. ... RNA interactions central to RNA interference. The molecular architecture of Dicer is known, shedding light on how different Dicers produce products of varying lengths. ... MacRae IJ, Kirsch JF, Doudna JA ...
  5. sciencedirect.com

    RNA interference (RNAi) is a mechanism for gene silencing/inactivation that represses gene expression by means of small non-coding RNAs (sRNAs) in eukaryotic organisms (Nicolás and Garre, 2017). In filamentous fungi, the gene silencing effects triggered by RNAi were firstly observed in N. crassa , a phenomenon that was initially called ...
  6. Understanding how such information is differentially and dynamically retrieved to define distinct cell types and cellular states is a major challenge facing molecular biology. Gene regulatory factors that control the expression of genomic information come in a variety of flavors, with transcription factors and microRNAs representing the most ...
    Author:Oliver HobertPublished:2008
  7. By combining carefully designed reporter constructs with microscopy, flow cytometry, and RNA interference, Berkovits and Mayr were able to illuminate a chain of molecular events that switch the localization and function of CD47 protein, depending on whether it is translated from an mRNA isoform harboring either the short or long 3'UTR (with ...
  8. pmc.ncbi.nlm.nih.gov

    In many organisms, intergenic or antisense transcription gives rise to different classes of small RNAs and long non-coding RNAs (lncRNAs) that have emerged as key regulators of chromatin structure in eukaryotic cells 1,2.In addition to their roles in RNA degradation and translational repression, small RNAs modify chromatin and target gene expression via RNA interference (RNAi) pathways 3-11 ().
  9. biology.mit.edu

    Professor Emeritus of Biology Paul Schimmel PhD '67 and his wife Cleo Schimmel are among the biggest champions and supporters of graduate students conducting life science research in the Department of Biology at MIT, as well as in departments such as the Department of Brain and Cognitive Sciences, the Department of Biological Engineering, and the […]
  10. researchgate.net

    Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organisms. The silencing of a gene is a consequence of degradation of RNA ...

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