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  1. ijidonline.com

    Jun 8, 2024Infectious diseases remain a leading global cause of morbidity and mortality [1]. Even in rich countries with health services and antibiotics availability, respiratory tract infections are a major cause of death [1]. In addition, the treatment or prevention of infection is vital for high-quality maternal and child health, management of immunosuppressed patients, and many surgical procedures.
  2. pubmed.ncbi.nlm.nih.gov

    Host-directed therapies: old and new approaches for the treatment of infections. Host-directed therapies: old and new approaches for the treatment of infections Int J Infect Dis. 2024 Jun 9:146:107130. doi: 10.1016/j.ijid.2024.107130. Online ahead of print. Authors ...
  3. ijidonline.com

    Host-directed therapies: old and new approaches for the treatment of infections Infectious diseases remain a leading global cause of morbid- ity and mortality [1]. Even in rich countries with health services and antibiotics availability, respiratory tract infections are a ma- jor cause of death [1]. In addition, the treatment or prevention of
  4. pmc.ncbi.nlm.nih.gov

    A range of host-directed therapies have been identified with different mechanisms of action , and they are now regarded as viable adjuncts to standard antimicrobial treatment. Host-directed therapies can improve host cellular responses to pathogens, target disease-causing virulence factors , and activate innate and adaptive immune responses and ...
  5. pmc.ncbi.nlm.nih.gov

    Host-directed therapies are a relatively new and promising approach to treatment of tuberculosis. Modulation of specific host immune pathways, including those that impact inflammation and immunopathology, can limit mycobacterial infection and pathology, both in cell culture and in animal models.
  6. researchgate.net

    Jun 1, 2024Request PDF | On Jun 1, 2024, Delia Goletti and others published Host-directed therapies: old and new approaches for the treatment of infections | Find, read and cite all the research you need on ...
  7. pmc.ncbi.nlm.nih.gov

    On the other hand, modulation of certain immunosuppressive immune responses may enhance the innate bactericidal activity of the immune system and thus accelerate bacterial clearance. Repurposing drugs that are safe and approved for human use is an approach that may fast-track the clinical development of new host-directed TB treatment regimens.
  8. link.springer.com

    Dec 8, 2023As discussed above, HDT targets specific host factors that otherwise tend to help the pathogen. HDT works independently as an antibacterial approach and also acts synergistically with other drugs like antibiotics as adjunctive therapies (Rayasam and Balganesh 2015).In HDT, the target proteins are from the host, some of which could be the target of some existing drugs against non-infectious ...
  9. pubmed.ncbi.nlm.nih.gov

    Oct 1, 2024New and emerging pathogens, such as SARS-CoV2 have highlighted the requirement for threat agnostic therapies. Some antibiotics or antivirals can demonstrate broad-spectrum activity against pathogens in the same family or genus but efficacy can quickly reduce due to their specific mechanism of action and for the ability of the disease causing agent to evolve.
  10. thelancet.com

    Multidrug-resistant (MDR) tuberculosis remains a major threat to global public health security, despite advances that include new tuberculosis drugs, treatment regimens, and rapid diagnostics. In 2018, there were an estimated half a million new cases of rifampicin-resistant tuberculosis; 78% of these cases had MDR tuberculosis.1 Current WHO treatment recommendations for MDR tuberculosis ...
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