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  1. pubmed.ncbi.nlm.nih.gov

    May 24, 2023Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis Front Immunol. 2023 May 24:14:1146704. doi: 10.3389 ... Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. ... Linea 4 and ...
  2. frontiersin.org

    May 11, 2023Figure 1 Age-related immune alterations in infectious diseases. Impact of age on the innate and adaptive immunity in COVID-19, HIV and tuberculosis (TB). Aging may lead to modifications of both innate and adaptive immunity arms that induce a dysfunctional immune response against viral or bacterial infections, which includes increased cytokines release, downregulation of APCs, T and B cell ...
  3. frontiersin.org

    Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis Alba Grifoni1 †, Tonino Alonzi2, Galit Alter3, Douglas McClain Noonan4,5, Alan L. Landay6, Adriana Albini7* and Delia Goletti2* 1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, United States, 2Translational Research Unit, National Institute for Infectious ...
  4. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and includes COVID-19, HIV and tuberculosis. Keywords. aging innate cells B cells T cells COVID-19 tuberculosis Published in Frontiers in Immunology ISSN 1664-3224 (Online) Publisher
  5. researchexperts.utmb.edu

    Since the impact of aging on immune function, is still to be fully elucidated, this review addresses some of the recent understanding of age-related changes affecting key components of immunity. The emphasis is on immunosenescence and inflammaging that are impacted by common infectious diseases that are characterized by a high mortality, and ...
  6. pmc.ncbi.nlm.nih.gov

    Therefore, better understanding of the pathophysiology of aging and the immune response will not only help understand age-related diseases but also guide targeted management strategies for deadly infectious diseases like COVID-19. Keywords: aging, immunity, coronavirus, SARS-CoV, COVID-19, infection, immune response. Introduction
  7. journals.aai.org

    Current research shows a decrease in pro-inflammatory cytokines but the downstream signaling pathways in the context of aging have yet to be evaluated. Two critical pathway points in the production of type I IFN are the phosphorylation of pIRF7 in the TLR 7/8 pathway and of pTBK-1 in the RIG-I and cGAS-STING pathways.
  8. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC9002045

    Most people who are infected with M. tuberculosis do not develop primary disease but mount a sufficient immune response to control, but not eradicate infection, called latent tuberculosis infection (LTBI). 26, 27 When host immunity breaks down, because of co-infection with HIV, treatment with biological agents such as monoclonal antibodies ...
  9. pubmed.ncbi.nlm.nih.gov

    The impact of aging and COVID-19 on our immune system: a high-resolution map from single cell analysis Protein Cell. 2020 Oct;11(10):703-706. doi: 10.1007/s13238-020-00782-y. Authors Jing Yang 1 , Hao Li 2 Affiliations 1 School of Medicine, University of Electronic Science ...
  10. The search for an effective vaccine for COVID-19 should also consider the decreased vaccination efficacy in older individuals that may be associated with inflammaging . Therefore, the effective treatment of COVID-19 patients may require a combination of anti-inflammatory and antiviral regimes to complement vaccination against the virus.

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