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  1. researchgate.net

    Feb 20, 2023These test performances have been overcome by a recently developed rapid chemiluminescence assay, which recognizes VITT antibodies but not most HIT antibodies, 17 and by modifying the functional ...
  2. semanticscholar.org

    Feb 1, 2023DOI: 10.1055/s-0042-1760584 Corpus ID: 257652401; Developing an assay to distinguish between HIT and VITT antibodies @article{Schnborn2023DevelopingAA, title={Developing an assay to distinguish between HIT and VITT antibodies}, author={Linda Sch{\"o}nborn and Jan Wesche and Julia Fuhrmann and Orenes Pinero Esteban and Paula Dobosz and Maria Ni{\~n}o Broto and Josep Serra and Roser Llevadot and ...
  3. ashpublications.org

    Dec 8, 2023New immunoassays can differentiate between HIT-like and VITT-like antibodies in the research laboratory. Widely applicable assays that can differentiate among these various anti-PF4 disorders are needed to evaluate systematically the prevalence of these antibodies in different patient cohorts. ... Developing an assay to distinguish between HIT ...
  4. sciencedirect.com

    Dec 28, 2023Although both HIT and VITT antibodies usually test positive by standard microtiter-based anti-PF4/heparin enzyme-immunoassays (EIAs), the anti-PF4 antibodies in patients with VITT differ from the anti-PF4/heparin antibodies implicated in HIT. ... (Tecniospring INDUSTRY) ... Developing an assay to distinguish between HIT and VITT antibodies ...
  5. pmc.ncbi.nlm.nih.gov

    Immunoassays to Distinguish between HIT and VITT Antibodies. The key report by Huynh and colleagues 49 indicating that there are distinct epitopes on PF4 recognized by cHIT versus VITT antibodies implies that it ought to be possible to develop immunoassays that distinguish reliably between VITT and HIT antibodies. VITT sera can yield positive ...
  6. thieme-connect.com

    We have developed an assay, which can distinguish between HIT and VITT antibodies and can be used in any hospital laboratory. Method Confirming platelet-activation assays (HIPA and PIPA) were performed as described. We defined 3 cohorts: 1) Negative controls (n=112, including 35 healthy donors from before 2020, 46 clinical patients suspected ...
  7. ash.confex.com

    Recent development of new assays to distinguish between HIT and VITT-like anti-PF4 antibodies has led to recognition of patients with severe acute (sometimes chronic, recurrent) thrombosis and thrombocytopenia, where VITT-mimicking (rather than HIT-mimicking) anti-PF4 antibodies are implicated, independent of proximate heparin exposure or ...
  8. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC10862238

    Dec 12, 2023Serologically, the underlying cause is presence of anti-PF4 antibodies detected by anti-PF4/heparin EIAs, with features that are unlike HIT but rather characteristic of VITT ("VITT-like antibodies"), that is, negative testing by a rapid chemiluminescence test for HIT antibodies, 19 negative or weakly positive testing by functional assay in ...
  9. ashpublications.org

    The widely used laboratory assessment for HIT antibodies is an enzyme-linked immunosorbent assay (ELISA) that detects antibodies against H-PF4. These assays are highly sensitive; however, they have only moderate specificity. The lower specificity is due to the nonpathogenic antibodies being indistinguishable from the true HIT-causing antibodies.
  10. sciencedirect.com

    Laboratory testing for VITT antibodies is crucial for VITT diagnosis. Like HIT [6, 7], VITT can be considered a "clinical-pathological" disorder.This denotes that detectability of platelet-activating anti-PF4 antibodies is one of the key criteria underlying diagnosis of VITT, along with a compatible clinical picture that features thrombocytopenia and/or thrombosis (usually both) occurring ...

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