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  1. Based on this study, we envision a novel approach focused on inhibiting mechanotransduction, which is not a conventional target in oncology therapy. We aim to identify small molecule inhibitors that bind and stabilize the target, prevent its unfolding, and thus block the interaction and subsequent mechanotransduction. We have developed a ...
  2. Title: Inhibiting mechanotransduction as a novel approach for oncology therapy Speakers: Mamatha Bangalore Nijaguna, Ignacio Viciano Gonzalo, Anabel-Lise Le Roux, Pere Roca-Cusachs Congress: Mechanobiology of cancer summer school Country: ESP City: Prullans Organizing institutions: Year: 2022
  3. ibecbarcelona.eu

    Institute for Bioengineering of Catalonia (IBEC)

    https://ibecbarcelona.eu › cellmolmech

    Apr 10, 2024INTROPY INhibiting mechanoTRansduction for Oncology theraPY (2021-2023) ACCIO, Tecniospring Industry: Mamatha Nijaguna: INTERNATIONAL PROJECTS FINANCER PI; MECHANOCONTROL · Mechanical control of biological function (2017-2021) ... Inhibiting mechanostransduction as a novel therapy in the treatment of solid tumors (2017-2018) Obra Social La Caixa:
  4. Title: Inhibiting mechanotransduction as a novel approach for oncology therapy Speakers: Mamatha Bangalore Nijaguna, Ignacio Viciano Gonzalo, Anabel-Lise Le Roux, Pere Roca-Cusachs. Congress: 15th IBEC Symposium - Bioengineering for Active Ageing Country: ESP City: Barcelona Organizing institutions: Year: 2022
  5. sciencedirect.com

    Jan 1, 2024By inhibiting the membrane contraction and encouraging protrusion at the leading edge of cells, ... Blocking the mechanotransduction can be a novel approach to treat the cancer by inhibiting such pathways, which will be a promising new direction for cancer research. ... targets for cancer diagnosis and therapy? Cancers (Basel) (2021), p. 13 ...
  6. sciencedirect.com

    Mar 1, 2023To date, the nuclear mechanophenotypes of cancer cells have been shown to differ from those of normal cells (e.g., Young's modulus, viscosity, mechanotransduction), and such difference has been explored for providing useful references in developing new cancer therapeutic approaches.In the current review, we first introduce the alteration of nuclear composition, structure, and mechanics of ...
  7. sciencedirect.com

    2 days agoMechanotransduction is the cellular process by which mechanical cues from the external environment are sensed and converted into intracellular signals. ... inhibiting cancer cell migration and invasion ... Implications of farnesyltransferase and its inhibitors as a promising strategy for cancer therapy. Semin. Cancer Biol., 56 (2019), pp. 128-134.
  8. ejcancer.com

    provide novel combinatorial regimens to reverse drug resistance, as well as offer un-precedented targeting approaches that may help to more effectively treat a large proportion of solid tumours and their complications. Here, we highlight recent findings regarding various aspects of tumour mechanobiology in
  9. Thereafter, we provide a deeper discussion on the recent nanoengineering approaches for fine-tuning ligand presentation, such as ligand density and spatial organization to optimize TCR activation, and novel surface decoration strategies developed for direct enhancement or inhibition of mechanotransduction pathways in T cells.

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