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  1. pubmed.ncbi.nlm.nih.gov

    Hyperosmolar expansion medium improves nucleus pulposus cell phenotype JOR Spine. 2022 Aug 18 ... with tissue-specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell-based therapy has been hampered by the low cell numbers that can be extracted from donor ...
  2. ncbi.nlm.nih.gov

    National Center for Biotechnology Information

    https://www.ncbi.nlm.nih.gov › pmc › articles › PMC9520765

    Hyperosmolar expansion medium improves the phenotype of dog nucleus pulposus cells (NPCs) independent of oxygen level. (A) Fold changes in relative gene expression of NPC and progenitor markers after expansion of two passages in both normoxic (NX: 21% O 2 ) and hypoxic (HX: 5% O 2 ) conditions in the different media osmolarities (lines indicate ...
    Publication:JOR Spine. 2022 Sep; 5(3): e1219.
  3. onlinelibrary.wiley.com

    Yet the applicability of NPCs as cell-based therapy has been hampered by the low cell numbers that can be extracted from donor IVDs and their potentially limited regenerative capacity due to their degenerated phenotype. To optimize the expansion conditions, we investigated the effects of increasing culture medium osmolarity during expansion on ...
  4. A promising strategy to optimize the expansion of these cells outside of the body is to focus on factors that influence the nucleus pulposus cell's phenotype. Studies in humans show that increasing the concentration of particles dissolved in the lab's culture medium - in other words increasing osmolarity - enhances the phenotype and ...
  5. researchgate.net

    Conclusions: Altogether, our findings show that increasing medium osmolarity during expansion results in an NPC population with improved phenotype, which could enhance the potential of cell-based ...
  6. semanticscholar.org

    This work investigated the effects of increasing culture medium osmolarity during expansion on the phenotype of dog NPCs and their ability to produce a healthy extracellular matrix (ECM) in a 3D culture model. Repopulating the degenerated intervertebral disc (IVD) with tissue‐specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the ...
  7. shura.shu.ac.uk

    Background:Repopulating the degenerated intervertebral disc (IVD) with tissue-spe-cific nucleus pulposus cells (NPCs) has already been shown to promote regenerationin various species. Yet the applicability of NPCs as cell-based therapy has been ham-pered by the low cell numbers that can be extracted from donor IVDs and theirpotentially limited regenerative capacity due to their degenerated ...
  8. sigmaaldrich.com

    Hyperosmolar expansion medium improves nucleus pulposus cell phenotype. by Lisanne T Laagland, Frances C Bach, Laura B Creemers, Christine L Le Maitre, Deepani W Poramba-Liyanage, Marianna A Tryfonidou. JOR spine. Read more related scholarly scientific articles and abstracts.
  9. dspace.library.uu.nl

    Background: Repopulating the degenerated intervertebral disc (IVD) with tissue-specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell-based therapy has been hampered by the low cell numbers that can be extracted from donor IVDs and their potentially limited

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