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  1. Jan 14, 2025While the treatment had little effect on the two popular senescence markers p16 and p21, it did significantly reduce the secretion of the major pro-inflammatory SASP factors interleukin 6 (IL-6) and interleukin 8 (IL-8) as well as the expression of the corresponding genes in both models of senescence.
  2. pmc.ncbi.nlm.nih.gov

    In this regard, diverse metabolites of the gut microbiome and probiotic bacteria, or microbiome-fermented dietary phytomolecules are known to exert strong anti-inflammatory and antioxidant attributes which may be useful in preventing senescence-associated pro-inflammatory and pro-tumorigenic environment [137-142] (Fig. 3).
  3. sciencedirect.com

    Many researches have reported an interaction between dietary patterns and a lower risk of aging and aging-related diseases, and these dietary patterns could help mitigate aging or improve aging-related diseases by regulating aging-induced changes in the gut microbiota and its metabolites, improving the gut barrier, and reducing inflammation ...
  4. pmc.ncbi.nlm.nih.gov

    A summary of the multifaceted features of senescent cells and their impact on the gut microbiome. Cellular senescence arises from myriad stimuli, including DNA damage, telomere shortening, and oxidative stress, which disrupt normal cellular functions and induce cell cycle arrest through key pathways such as p16 INK4A ‐pRB and p53-p21 WAF1/CIP1. ...
  5. sciencedirect.com

    Dec 1, 2024Polysaccharides, the main active ingredients of TCM, have been widely studied for their rich pharmacological activities, such as anti-inflammatory, antioxidant, and anti-tumor effects (Li et al., 2020a; Shao et al., 2014; Tian et al., 2023).Among them, the regulation of gut microbiota is the main way by which the polysaccharides in TCM exert pharmacological activity, mainly because the gut ...
  6. link.springer.com

    In this regard, diverse metabolites of the gut microbiome and probiotic bacteria, or microbiome-fermented dietary phytomolecules are known to exert strong anti-inflammatory and antioxidant attributes which may be useful in preventing senescence-associated pro-inflammatory and pro-tumorigenic environment [137,138,139,140,141,142] (Fig. 3).
  7. pubmed.ncbi.nlm.nih.gov

    The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis in the aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, and predisposition to age-associated diseases. Cellular senescence, …
  8. sciencedirect.com

    Aug 1, 2024Based on these findings, we propose the following model for the relationship between gut microbiota and cellular senescence with aging. With aging, the gut barrier breaks down and Gram-negative bacteria invade ileal tissues and stimulate GC B cells, resulting in cellular senescence, which in turn reduces IgA production and diversity, leading to ...
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