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https://www.science.org › doi › 10.1126 › sciadv.ado7120
Efficacy and specificity of inhibitors of BCL-2 family ... - Science
(A) Schematic representations of the human amino acid (aa) sequence for the analyzed BCL-2 family proteins (1-5). BH regions are indicated with numbers 1 to 4, with the BH3 region indicated in red; membrane-binding region types are specified.
BCL6 promotes a stem-like CD8 + T cell program in cancer via ... - Science
Intratumoral exhausted CD8 + stem- or progenitor-like (T prog) and terminally differentiated (T term) cells mediate antitumor immunity and response to immunotherapy.Sun et al. investigated how exhausted CD8 + T cells are transcriptionally regulated in murine tumor models, identifying that the transcription factors BCL6 and BLIMP1 reciprocally regulate T prog and T term cell fates, respectively.