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  1. Multiplex genome editing, or the simultaneous targeting of multiple specific DNA loci in a genome, represents another area where CRISPR-induced gene knockout technology has been scaled up and adapted into a successful platform—particularly in the plant science fields [reviewed in (68, 69)] . Over the past decade, CRISPR-Cas9 has become a ...
    • RNA editing with CRISPR-Cas13 | Science - AAAS

      Precise nucleic acid-editing technologies are valuable for studying cellular function and as novel therapeutics. Current editing tools, based on programmable nucleases such as the prokaryotic CRISPR-associated nucleases Cas9 (1-4) or Cpf1 (), have been widely adopted for mediating targeted DNA cleavage, which in turn drives targeted gene disruption through nonhomologous end joining (NHEJ ...

    • Repair of CRISPR-guided RNA breaks enables site ... - Science | AAAS

      CRISPR-guided endonucleases have enabled programable DNA cleavage and the development of new therapeutics (1, 2).The first generation of CRISPR genome editing used Cas9 nuclease to make double-stranded DNA breaks that are repaired by the cell, leading to site-specific edits ().These technologies have enriched our mechanistic understanding of DNA repair and new insights into repair are used to ...

  2. Precise nucleic acid-editing technologies are valuable for studying cellular function and as novel therapeutics. Current editing tools, based on programmable nucleases such as the prokaryotic CRISPR-associated nucleases Cas9 (1-4) or Cpf1 (), have been widely adopted for mediating targeted DNA cleavage, which in turn drives targeted gene disruption through nonhomologous end joining (NHEJ ...
    Author:David B. T. Cox, Jonathan S. Gootenberg, Omar O. Abudayyeh, Brian Franklin, Max J. Kellner, Julia Jo...Published:2017
  3. Apr 25, 2024CRISPR-guided endonucleases have enabled programable DNA cleavage and the development of new therapeutics (1, 2).The first generation of CRISPR genome editing used Cas9 nuclease to make double-stranded DNA breaks that are repaired by the cell, leading to site-specific edits ().These technologies have enriched our mechanistic understanding of DNA repair and new insights into repair are used to ...
  4. pmc.ncbi.nlm.nih.gov

    The actual genome editing occurs in the process of repairing double-strand breaks created by the CRISPR-Cas system. Two main pathways are responsible for such repair: homology-directed repair and non-homologous end joining (NHEJ), with NHEJ predominant in mammalian cells ().The homology-directed repair strategy requires a donor template with homology to the context sequence, which integrates ...
  5. pmc.ncbi.nlm.nih.gov

    Keywords: CRISPR, Cas9, genome editing, bioethics. Introduction. In the era of "gene editing," CRISPR-Cas9 has become hugely attractive for both the scientific community and the general public. The metaphorical use of the term "gene editing" gives the impression that genes as texts are static in nature and therefore can be corrected easily.
  6. U.S. Government Accountability Office (U.S. GAO)

    https://www.gao.gov › products › gao-20-478sp

    CRISPR is a gene editing technology that allows scientists to make specific, targeted changes to DNA. Scientists are using CRISPR to develop treatments for medical conditions, including blindness and some cancers, as well as to create tests to rapidly identify COVID-19 and other infections.
  7. britannica.com

    Dec 21, 2024Gene editing, the ability to make highly specific changes in the DNA sequence of a living organism. Gene editing is performed using specialized technologies, including enzymes engineered to target a specific DNA sequence. Key among gene-editing technologies is a molecular tool known as CRISPR-Cas9.
  8. pmc.ncbi.nlm.nih.gov

    Alternatively, supplying a DNA template in vivo with a desired mutation or more complex ... In work that is revolutionizing our ability to carry out gene editing, the CRISPR-Cas9 system from S. pyogenes has been ... Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science. 2014;346:1258096. doi: 10.1126 ...
  9. smithsonianmag.com

    Four U.S. CRISPR Trials Editing Human DNA to Research New Treatments. Breaking down how the gene editing technology is being used, for the first time in the United States, to treat patients with ...
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