1. mayoclinic.org

    The most common type of ALD is X-linked ALD, which is caused by a genetic defect on the X chromosome.X-linked ALD affects males more severely than females, who carry the disease.. Forms of X-linked ALD include:. Childhood-onset ALD. This form of X-linked ALD usually occurs between ages 4 and 10. The white matter of the brain is progressively damaged (leukodystrophy), and symptoms worsen over time.
  2. my.clevelandclinic.org

    Less-common types of ALD include: Adrenal insufficiency-only ALD: Some people have only Addison's disease, without any neurological problems. About 1 in 10 people with ALD have this type. Adult cerebral ALD: About 1 in 5 affected adult males develop cognitive problems similar to childhood cerebral ALD. Over time, they lose most of their mental and neurological function.
  3. mayoclinic.org

    Diagnosis. To diagnose ALD, your doctor will review your symptoms and your medical and family history.Your doctor will conduct a physical examination and order several tests, including: Blood testing. These tests check for high levels of very long-chain fatty acids (VLCFAs) in your blood, which are a key indicator of adrenoleukodystrophy.
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